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Cytisine (cytisinicline) uses a tightly scheduled 25-day taper to help you stop smoking by partly stimulating nicotine receptors in the brain, reducing craving while nicotine use stops. Take tablets with water at the intervals printed on the pack. Authorised products can differ between countries, so your supplied leaflet always takes priority over this guide.
Choose your quit date before or by day 5, and do not continue smoking or using nicotine products during treatment unless a clinician has explicitly advised a plan. Continued nicotine can worsen adverse effects.

How to use

The course has two conditions that hold throughout it — the pack schedule, and the quit date.

Follow the supplied 1.5 mg pack in order

Take tablets with water at the intervals printed on the pack.

Stop smoking no later than day 5

Choose the quit date before or by day 5 of the course.

Dose schedule

Take up to 6 tablets per day while reducing smoking and preparing to stop.
Take up to 5 tablets per day, and stop smoking no later than day 5.
Days 13–16 use one tablet every 3 hours, up to 4 daily. Days 17–20 use one every 5 hours, up to 3 daily.
Complete the final taper exactly as labelled. If the attempt is unsuccessful, stop the medicine and discuss when another attempt is appropriate rather than restarting immediately.

What has been reported

Contact your doctor if

  • Chest pain, fainting, stroke symptoms, a sustained abnormal heartbeat, or a severe allergic reaction — seek urgent care
  • Severe mood change, thoughts of self-harm, or symptoms that make continued treatment unsafe
  • You cannot stop smoking by day 5, used nicotine throughout treatment, missed several timed doses, or want to restart a course

Storage

Keep in the original package, away from moisture and direct heat, and out of children’s reach. Follow the temperature limit on your pack and do not use it after the expiry date.

What to expect

Cytisine partly stimulates nicotine receptors to reduce craving while nicotine use stops. The structured 25-day course and behavioural support can improve the chance of quitting, but results vary. Follow the exact pack schedule, use a firm quit date, and review an unsuccessful attempt with your doctor before repeating treatment.

Who it is not suitable for

The consultation screens for medical conditions that make cytisine unsuitable. Tell the doctor about any heart condition, history of seizures, severe kidney or liver disease, or pregnancy or breastfeeding before starting treatment.

Common questions

The product information does not list a specific interaction with alcohol. However, alcohol can weaken resolve during a quit attempt and may worsen side effects such as dizziness. Discuss your alcohol use with the prescribing doctor.
If you cannot stop smoking by day 5, used nicotine throughout treatment, or missed several timed doses, stop the medicine and discuss with your doctor when another attempt is appropriate. Do not restart immediately.
Both medicines partly stimulate nicotine receptors to reduce craving. Cytisine uses a 25-day taper whereas varenicline uses a different schedule. A doctor can discuss which approach may suit you better. See the varenicline guide.
The course is designed to stop nicotine entirely by day 5. Continued use of nicotine during treatment can worsen adverse effects. Do not continue smoking or using nicotine products unless a clinician has explicitly advised a plan.
Take the missed tablet as soon as you remember, then continue with the next scheduled dose. Do not double a dose to catch up. If you miss several doses, message the medical team for advice.
Some effects — irritability, anxiety, low mood, poor concentration and craving — may reflect nicotine withdrawal rather than the medicine. Digestive symptoms, sleep disturbance and vivid dreams are more likely from the medicine. Review the whole pattern with your doctor.

How Hi-Doctor handles it

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This page is reference information, not medical advice and not a prescription. Whether a medicine is appropriate for you is decided by a registered doctor after reviewing your consultation.